UPSC Weekly Current Affairs Quiz (June 21 – June 27)
GS3Economy · S&T · Environment · Security· Biotechnology & health research· Prelims + Mains·
Why in news
UPSC included Fixed-Dose Combinations (FDCs) in its Prelims syllabus due to concerns over irrational drug combinations and regulatory oversight.
Background
Fixed-dose combinations (FDCs) contain two or more active ingredients in a single formulation. A combination is deemed 'irrational' if there is no scientific evidence that the ingredients work better together than separately.
Facts for Prelims
- S&TFDCs: Formulations containing two or more active ingredients in a single product.
- FactIrrational FDCs: Combinations lacking scientifically established rationale for synergistic therapeutic effects.
- BodyRegulatory oversight: Drug authorities review and prohibit unsafe or irrational formulations in India.
For Mains
Q. Critically analyze the regulatory challenges in monitoring Fixed-Dose Combinations (FDCs) in India and suggest measures to ensure rational drug usage.
Dimensions to cover in your answer
- Regulatory oversight gap: Difficulty in monitoring thousands of FDC variants for clinical efficacy and safety.
- Public health risk: Proliferation of irrational combinations leading to potential drug resistance and adverse reactions.
- Policy trade-off: Balancing ease of patient compliance (single pill) against the necessity of evidence-based pharmacological synergy.
Keywords: Fixed-Dose Combinations · Irrational Drugs · Pharmacovigilance · Regulatory Oversight · Public Health Policy
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