Blue light triggers cell division fix: IISc team's breakthrough LISA technique
GS3Economy · S&T · Environment · Security· Biotechnology & health research· Prelims + Mains·
Optogenetics and protein engineering applications in cancer research: a GS3 Science & Technology topic.
Why in news
IISc researchers developed the LISA technique to reversibly activate Aurora A kinase using blue light to study and potentially rescue cell division defects.
Background
Prof. Sachin Kotak's team at IISc engineered human cells to express a fusion protein linking Aurora A to CRY2. The LISA technique allows for the clustering of these proteins upon exposure to blue light to manipulate spindle assembly.
Facts for Prelims
- S&TLISA: Light-Induced Spindle Activation technique developed by IISc
- S&TAurora A kinase: Protein crucial for spindle assembly during cell division
- S&TCRY2: Protein used in fusion to allow clustering upon blue light exposure
- FactLISA technique can be used to target Aurora A kinase in solid tumors
Prelims practice question
Which protein is used in the LISA technique to facilitate clustering upon exposure to blue light?
- (a)SOD1
- (b)GFP
- (c)CRY2
- (d)Aurora B
Show answer
Answer: (c) CRY2 — The note states that CRY2 is the protein used in the LISA technique to facilitate clustering upon blue light exposure.
For Mains
Q. Discuss how advancements in optogenetics and protein engineering, such as the LISA technique, can revolutionize targeted cancer therapies and cellular biology research.
Dimensions to cover in your answer
- Precision medicine: Targeted manipulation of Aurora A kinase to treat solid tumors
- Mechanistic insight: Reversible activation allows for real-time observation of spindle assembly defects
Keywords: Optogenetics · Protein Engineering · Cellular Biology · Targeted Therapy · Aurora A Kinase
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